While the Southeast USA is suitable for growing a wide variety of fruits and vegetables, there are some that are challenging to cultivate due to the region’s climate, which includes high humidity and long, hot summers. Some examples of fruits and vegetables that may be difficult to grow in the Southeast include:

1. Apples: While some apple varieties can be grown in the Southeast, they often require specific conditions and may not thrive as well as in cooler regions.
2. Cherries: Sweet cherries, in particular, have specific cold requirements for dormancy, making them challenging to grow in the Southeast’s warm climate.
3. Blueberries: Although blueberries are grown in the Southeast, some varieties are better suited to regions with cooler winters.
4. Cabbage: Cabbage can be susceptible to heat stress and pests in the Southeast’s hot, humid summers.
5. Asparagus: Asparagus prefers cooler climates and may not thrive in the Southeast’s warm conditions.
6. Brussels Sprouts: These cool-season crops may struggle in the Southeast’s heat.
7. Rhubarb: Rhubarb is a cold-climate plant and typically doesn’t do well in the Southeast’s climate.

However, it’s essential to note that advancements in agriculture and gardening techniques, as well as the use of specific cultivars and adaptations, may allow some of these crops to be successfully grown in the Southeast. Additionally, home gardeners can use protective measures like shade cloth and proper timing to overcome some of the challenges posed by the region’s climate. It’s always a good idea to consult with local agricultural extension services or gardening experts for specific recommendations on what can be grown successfully in your particular area within the Southeast.